News aggregator
Wadena, Minn., man missing, needs diabetes medication (The Fargo Forum)
Newer Blood Test Better at Predicting Heart Disease, Stroke Risk
Processed Meats Increase Heart Disease Risk: Study
Kaiser study urges early usage of diabetes drug (The Columbian)
Starting Treatment Early Doubles Chance Of Success For People With Diabetes (Medical News Today)
Vermont adults with Type 1 diabetes serve as mentors to youths with the disease (The Burlington Free Press)
Docs: Smith learned to control (not reverse) his diabetes (Chicago Sun-Times)
Starting metformin drug early can help prevent long-term complications of diabetes: Study (News-Medical-Net)
10 March 2010 - Interesting New Papers January 2010
Video: Updating diabetes management (Main Line Suburban Life)
Diamyd Medical enrolls over 430 children with newly diagnosed type 1 diabetes in global Phase III program (News-Medical-Net)
Bristol-Myers Squibb, AstraZeneca commence SAVOR-TIMI 53 trial of ONGLYZA for type 2 diabetes (News-Medical-Net)
Diabetes drug effective if taken early (UPI)
Wine May Fight Weight Gain in Women
09 March 2010 - A prediction of obesity trends for adults and their associated diseases
09 March 2010 - Guideline on self-monitoring of blood glucose in non-insulin treated type 2 diabetes
Starting treatment early doubles chance of success for people with diabetes (Science Daily)
09 March 2010 - Guideline on oral health for people with diabetes
09 March 2010 - Global guideline on pregnancy and diabetes
The Risk of Overall Mortality in Patients with Type 2 Diabetes Receiving Glipizide, Glyburide, or Glimepiride Monotherapy: A Retrospective Analysis
Sulfonylureas have historically been analyzed as a medication class, which may be inappropriate given the differences in properties inherent to the individual sulfonylureas: hypoglycemic risk, sulfonylurea receptor selectivity and effects on myocardial ischemic preconditioning. The purpose of this study was to assess the relationship of individual sulfonylureas and the risk of overall mortality in a large cohort of patients with type 2 diabetes.
Research Design and Methods:A retrospective cohort study was conducted using an academic health center enterprise-wide electronic health record (EHR) system to identify 11,141 patients with type 2 diabetes (4,279 initiators of monotherapy with glyburide, 4,325 initiators of monotherapy with glipizide, and 2,537 initiators of monotherapy with glimepiride), ≥ 18 years of age, with and without a history of coronary artery disease (CAD), and not on insulin or a non-insulin injectable at baseline. The patients were followed for mortality by documentation in the EHR and Social Security Death Index. Multivariable Cox models were used to compare cohorts.
Results:No statistically significant difference in the risk of overall mortality was observed among these agents in the entire cohort, but we did find evidence of a trend towards an increased overall mortality risk with glyburide vs. glimepiride (HR 1.36; CI 0.96-1.91) and glipizide vs. glimepiride (HR 1.39; 95% CI 0.99-1.96), in those with documented CAD.
Conclusions:Our results did not identify an increased mortality risk among the individual sulfonylureas but did suggest that glimepiride may be the preferred sulfonylurea in those with underlying CAD.
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